Houston Texans
| Week | Opponent | Date (EST) | TV |
|---|---|---|---|
| 1 | vs.  Indianapolis | Sun Sep 11 1:00 PM | CBS |
| 2 | @  Denver | Sun Sep 18 4:25 PM | CBS |
| 3 | @  Chicago | Sun Sep 25 1:00 PM | CBS |
| 4 | vs.  LA Chargers | Sun Oct 2 1:00 PM | CBS |
| 5 | @  Jacksonville | Sun Oct 9 1:00 PM | CBS |
| 6 | BYE | -- | -- |
| 7 | @  Las Vegas | Sun Oct 23 4:05 PM | CBS |
| 8 | vs.  Tennessee | Sun Oct 30 4:05 PM | CBS |
| 9 | vs.  Philadelphia | Thu Nov 3 8:15 PM | Amazon Prime Video |
| 10 | @  NY Giants | Sun Nov 13 1:00 PM | CBS |
| 11 | vs.  Washington | Sun Nov 20 1:00 PM | CBS |
| 12 | @  Miami | Sun Nov 27 1:00 PM | CBS |
| 13 | vs.  Cleveland | Sun Dec 4 1:00 PM | CBS |
| 14 | @  Dallas | Sun Dec 11 1:00 PM | FOX |
| 15 | vs.  Kansas City | Sun Dec 18 1:00 PM | CBS |
| 16 | @ Tennessee | Sat Dec 24 1:00 PM | CBS |
| 17 | vs. Jacksonville | Sun Jan 1 1:00 PM | CBS |
| 18 | @ Indianapolis | Sun Jan 8 1:00 PM | CBS |