Indianapolis Colts
| Week | Opponent | Date (EST) | TV |
|---|---|---|---|
| 1 | @  Houston | Sun Sep 11 1:00 PM | CBS |
| 2 | @  Jacksonville | Sun Sep 18 1:00 PM | CBS |
| 3 | vs.  Kansas City | Sun Sep 25 1:00 PM | CBS |
| 4 | vs.  Tennessee | Sun Oct 2 1:00 PM | FOX |
| 5 | @  Denver | Thu Oct 6 8:15 PM | Amazon Prime Video |
| 6 | vs. Jacksonville | Sun Oct 16 1:00 PM | CBS |
| 7 | @ Tennessee | Sun Oct 23 1:00 PM | CBS |
| 8 | vs.  Washington | Sun Oct 30 4:25 PM | FOX |
| 9 | @  New England | Sun Nov 6 1:00 PM | CBS |
| 10 | @  Las Vegas | Sun Nov 13 4:05 PM | CBS |
| 11 | vs.  Philadelphia | Sun Nov 20 1:00 PM | CBS |
| 12 | vs.  Pittsburgh | Mon Nov 28 8:15 PM | ESPN |
| 13 | @  Dallas | Sun Dec 4 8:20 PM | NBC |
| 14 | BYE | -- | -- |
| 15 | @  Minnesota | Sun Dec 18 1:00 PM | TBD |
| 16 | vs.  LA Chargers | Mon Dec 26 8:15 PM | ESPN |
| 17 | @  NY Giants | Sun Jan 1 1:00 PM | CBS |
| 18 | vs. Houston | Sun Jan 8 1:00 PM | CBS |