Kansas City Chiefs
| Week | Opponent | Date (EST) | TV |
|---|---|---|---|
| 1 | @  Arizona | Sun Sep 11 4:25 PM | CBS |
| 2 | vs.  LA Chargers | Thu Sep 15 8:15 PM | Amazon Prime Video |
| 3 | @  Indianapolis | Sun Sep 25 1:00 PM | CBS |
| 4 | @  Tampa Bay | Sun Oct 2 8:20 PM | NBC |
| 5 | vs.  Las Vegas | Mon Oct 10 8:15 PM | ESPN |
| 6 | vs.  Buffalo | Sun Oct 16 4:25 PM | CBS |
| 7 | @  San Francisco | Sun Oct 23 4:25 PM | FOX |
| 8 | BYE | -- | -- |
| 9 | vs.  Tennessee | Sun Nov 6 8:20 PM | NBC |
| 10 | vs.  Jacksonville | Sun Nov 13 1:00 PM | CBS |
| 11 | @ LA Chargers | Sun Nov 20 4:25 PM | CBS |
| 12 | vs.  LA Rams | Sun Nov 27 4:25 PM | FOX |
| 13 | @  Cincinnati | Sun Dec 4 4:25 PM | CBS |
| 14 | @  Denver | Sun Dec 11 8:20 PM | NBC |
| 15 | @  Houston | Sun Dec 18 1:00 PM | CBS |
| 16 | vs.  Seattle | Sat Dec 24 1:00 PM | FOX |
| 17 | vs. Denver | Sun Jan 1 1:00 PM | CBS |
| 18 | @ Las Vegas | Sat Jan 7 4:30 PM | ESPN/ABC |