Los Angeles Chargers
| Week | Opponent | Date (EST) | TV |
|---|---|---|---|
| 1 | vs.  Las Vegas | Sun Sep 11 4:25 PM | CBS |
| 2 | @  Kansas City | Thu Sep 15 8:15 PM | Amazon Prime Video |
| 3 | vs.  Jacksonville | Sun Sep 25 4:05 PM | CBS |
| 4 | @  Houston | Sun Oct 2 1:00 PM | CBS |
| 5 | @  Cleveland | Sun Oct 9 1:00 PM | CBS |
| 6 | vs.  Denver | Mon Oct 17 8:15 PM | ESPN |
| 7 | vs.  Seattle | Sun Oct 23 4:25 PM | FOX |
| 8 | BYE | -- | -- |
| 9 | @  Atlanta | Sun Nov 6 1:00 PM | FOX |
| 10 | @  San Francisco | Sun Nov 13 8:20 PM | NBC |
| 11 | vs. Kansas City | Sun Nov 20 4:25 PM | CBS |
| 12 | @  Arizona | Sun Nov 27 4:05 PM | CBS |
| 13 | @ Las Vegas | Sun Dec 4 4:25 PM | CBS |
| 14 | vs.  Miami | Sun Dec 11 4:05 PM | CBS |
| 15 | vs.  Tennessee | Sun Dec 18 4:25 PM | CBS |
| 16 | @  Indianapolis | Mon Dec 26 8:15 PM | ESPN |
| 17 | vs.  LA Rams | Sun Jan 1 8:20 PM | NBC |
| 18 | @ Denver | Sun Jan 8 4:25 PM | CBS |