San Francisco 49ers
| Week | Opponent | Date (EST) | TV |
|---|---|---|---|
| 1 | @  Chicago | Sun Sep 11 1:00 PM | FOX |
| 2 | vs.  Seattle | Sun Sep 18 4:05 PM | FOX |
| 3 | @  Denver | Sun Sep 25 8:20 PM | NBC |
| 4 | vs.  LA Rams | Mon Oct 3 8:15 PM | ESPN |
| 5 | @  Carolina | Sun Oct 9 4:05 PM | CBS |
| 6 | @  Atlanta | Sun Oct 16 1:00 PM | FOX |
| 7 | vs.  Kansas City | Sun Oct 23 4:25 PM | FOX |
| 8 | @ LA Rams | Sun Oct 30 4:25 PM | FOX |
| 9 | BYE | -- | |
| 10 | vs.  LA Chargers | Sun Nov 13 8:20 PM | NBC |
| 11 | @  Arizona | Mon Nov 21 8:00 PM | ESPN |
| 12 | vs.  New Orleans | Sun Nov 27 4:25 PM | FOX |
| 13 | vs.  Miami | Sun Dec 4 4:05 PM | FOX |
| 14 | vs.  Tampa Bay | Sun Dec 11 4:25 PM | FOX |
| 15 | @ Seattle | Thu Dec 15 8:15 PM | Amazon Prime Video |
| 16 | vs.  Washington | Sat Dec 24 4:05 PM | CBS |
| 17 | @  Las Vegas | Sun Jan 1 4:05 PM | FOX |
| 18 | vs. Arizona | Sun Jan 8 4:25 PM | FOX |