| Week | AWAY | HOME | DATE (EST) | TV | Location |
|---|---|---|---|---|---|
| 2 | LA Chargers | @ Kansas City | Thu Sep 15 8:15 PM | Amazon Prime Video | GEHA Field at Arrowhead Stadium, Kansas City, MO |
| 3 | Pittsburgh | @ Cleveland | Thu Sep 22 8:15 PM | Amazon Prime Video | FirstEnergy Stadium, Cleveland, OH |
| 4 | Miami | @ Cincinnati | Thu Sep 29 8:15 PM | Amazon Prime Video | Paycor Stadium, Cincinnati, OH |
| 5 | Indianapolis | @ Denver | Thu Oct 6 8:15 PM | Amazon Prime Video | Empower Field at Mile High, Denver, CO |
| 6 | Washington | @ Chicago | Thu Oct 13 8:15 PM | Amazon Prime Video | Soldier Field, Chicago, IL |
| 7 | New Orleans | @ Arizona | Thu Oct 20 8:15 PM | Amazon Prime Video | State Farm Stadium, Glendale, AZ |
| 8 | Baltimore | @ Tampa Bay | Thu Oct 27 8:15 PM | Amazon Prime Video | Raymond James Stadium, Tampa, FL |
| 9 | Philadelphia | @ Houston | Thu Nov 3 8:15 PM | Amazon Prime Video | NRG Stadium, Houston, TX |
| 10 | Atlanta | @ Carolina | Thu Nov 10 8:15 PM | Amazon Prime Video | Bank of America Stadium, Charlotte, NC |
| 11 | Tennessee | @ Green Bay | Thu Nov 17 8:15 PM | Amazon Prime Video | Lambeau Field, Green Bay, WI |
| 13 | Buffalo | @ New England | Thu Dec 1 9:15 PM | Amazon Prime Video | Gillette Stadium, Foxboro, MA |
| 14 | Las Vegas | @ LA Rams | Thu Dec 8 8:15 PM | Amazon Prime Video | SoFi Stadium, Inglewood, CA |
| 15 | San Francisco | @ Seattle | Thu Dec 15 8:15 PM | Amazon Prime Video | Lumen Field, Seattle, WA |
| 16 | Jacksonville | @ NY Jets | Thu Dec 22 8:15 PM | Amazon Prime Video | MetLife Stadium, East Rutherford, NJ |
| 17 | Dallas | @ Tennessee | Thu Dec 29 8:15 PM | Amazon Prime Video | Nissan Stadium, Nashville, TN |