Buffalo Bills
| Week | Opponent | Date (EST) | TV |
|---|---|---|---|
| 1 | @  LA Rams | Thu Sep 8 8:20 PM | NBC |
| 2 | vs.  Tennessee | Mon Sep 19 7:15 PM | ESPN |
| 3 | @  Miami | Sun Sep 25 1:00 PM | CBS |
| 4 | @  Baltimore | Sun Oct 2 1:00 PM | CBS |
| 5 | vs.  Pittsburgh | Sun Oct 9 1:00 PM | CBS |
| 6 | @  Kansas City | Sun Oct 16 4:25 PM | CBS |
| 7 | BYE | -- | -- |
| 8 | vs.  Green Bay | Sun Oct 30 8:20 PM | NBC |
| 9 | @  NY Jets | Sun Nov 6 1:00 PM | CBS |
| 10 | vs.  Minnesota | Sun Nov 13 1:00 PM | FOX |
| 11 | vs.  Cleveland | Sun Nov 20 1:00 PM | CBS |
| 12 | @  Detroit | Thu Nov 24 12:30 PM | CBS |
| 13 | @  New England | Thu Dec 1 8:15 PM | Amazon Prime Video |
| 14 | vs. NY Jets | Sun Dec 11 1:00 PM | CBS |
| 15 | vs. Miami | Sun Dec 18 1:00 PM | TBD |
| 16 | @  Chicago | Sat Dec 24 1:00 PM | CBS |
| 17 | @  Cincinnati | Mon Jan 2 8:30 PM | ESPN |
| 18 | vs. New England | Sun Jan 8 1:00 PM | CBS |